#AL ATOMIC RADIUS PLUS#
An atomic chemical potential is constructed by using these quantities plus shielded electrostatic interactions between all charges. The input data are experimental atomic ionization potentials, electron affinities, and atomic radii. Recent Patents on CNS Drug Discovery (Discontinued) Glycerophospholipid Synthesis as a Novel Drug Target Against CancerĬurrent Molecular Pharmacology Hypoxia and Inflammation in Prostate Cancer Progression.Abstract: We report here an approach for predicting charge distributions in molecules for use in molecular dynamics simulations. Drugs Advances in Clinical TrialsĬurrent Medicinal Chemistry Dual-Targeted Molecular Probes for Cancer ImagingĬurrent Pharmaceutical Biotechnology CannabinoidsĬurrent Drug Targets - CNS & Neurological Disorders Search for Distinctive Markers in DNT and Cortical Grade II Glioma in Children: Same Clinicopathological and Molecular Entities?Ĭurrent Topics in Medicinal Chemistry Dendrimers as Novel Systems for Delivery of Neuropharmaceuticals to the BrainĬNS & Neurological Disorders - Drug Targets Cell Metabolism Under Microenvironmental Low Oxygen Tension Levels in Stemness, Proliferation and PluripotencyĬurrent Molecular Medicine Cerebral Arachidonate Cascade in Dementia: Alzheimers Disease and Vascular DementiaĬurrent Neuropharmacology Recent Advances in the Use of Metallic Nanoparticles with Antitumoral Action - ReviewĬurrent Medicinal Chemistry Poly(lactide-co-glycolide)-based Micro and Nanoparticles for the Controlled Drug Delivery of VitaminsĬurrent Nanoscience Suicide Gene Therapy Mediated by the Herpes Simplex Virus Thymidine Kinase Gene / Ganciclovir System: Fifteen Years of ApplicationĬurrent Gene Therapy Macrophages in Immunopathology of Atherosclerosis: A Target for Diagnostics and TherapyĬurrent Pharmaceutical Design Effect of Curcumin on Pro-angiogenic Factors in the Xenograft Model of Breast CancerĪnti-Cancer Agents in Medicinal Chemistry Imaging of Integrins as Biomarkers for Tumor AngiogenesisĬurrent Pharmaceutical Design Patent Selections: Hypoxia in Du-145 Prostate Cancer Xenografts After Estramustine Phosphate and RadiotherapyĬurrent Radiopharmaceuticals microRNAs, Gap Junctional Intercellular Communication and Mesenchymal Stem Cells in Breast Cancer MetastasisĬurrent Cancer Therapy Reviews Hypoxia Inducible Factor-1 in Cancer Immune SuppressionĬurrent Immunology Reviews (Discontinued) Anticancer Drug Design Using Scaffolds of β-Lactams, Sulfonamides, Quinoline, Quinoxaline and Natural Products. Radar Systems and Remote Sensing Lab of School, Electrical & Computer Engineering, National Technical University of Athens, Athens,Greece.Title:A Discussion Regarding the Application of the Hertz Contact Theory on Biological Samples in AFM Nanoindentation ExperimentsĪuthor(s): Stylianos Vasileios Kontomaris*, Andreas Stylianou, Konstantina S. Keywords: Mechanical properties, hertz model, biological samples, Atomic Force Microscopy (AFM), nanoindentation, To reduce the errors produced by the current methodology (Hertz model). The same experimental results when these are processed using the Hertz model and the Oliver & PharrĪnalysis (which is the general model that applies for any axisymmetric indenter) is provided.Ĭonclusion: A complete and reliable theoretical tool was developed (that takes into account the indentationĭepth/indenter’s radius ratio and the shape of the sample) which can be generally applied in order Moreover,Ī rational explanation, regarding the extended differences of the Young’s modulus calculations using Results: Several examples in the literature that do not take into account the value of the ratio indentationĭepth/indenter’s radius are reported and the related errors are calculated and discussed. The derived equation is further combined with equations which take into account the Methods: An extended new equation is derived which takes into account the influence of the indentationĭepth/indenter’s radius ratio on the calculation of the Young’s modulus and can be easily used forĬalculations. Hertz theory that depend on the ratio, indentation depth/indenter’s radius regarding the Young’s modulus Objective: This paper focuses on the investigation of the resulting errors of the basic equation of the Used theoretical model for data processing at the linear elastic regime regarding biological samples is
Methods and certain approximations regarding the theoretical analysis. TheseĬhallenges are related to the inhomogeneity of biological samples, various uncertainties in experimental Samples poses significant challenges with respect to the accuracy of the provided results.
Background: Atomic Force Microscopy (AFM) Nanoindentation procedure regarding biological
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